SHARP/autoSHARP

  • an automated structure solution pipeline built around the heavy-atom refinement and phasing program SHARP, the density modification program SOLOMON, and the ARP/wARP package for automated model building and refinement (using REFMAC). It allows fully automated structure solution, from merged reflection data to an initial model, without any user intervention.

Developers

Gerard Bricogne

Clemens Vonrhein

Categories

X-ray Crystallography

Versions

Citations

SHARP: Bricogne et al. Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0. Acta Cryst. 2003. D59: 2023-2030.

autoSHARP: Vonrhein et al. Automated structure solution with autoSHARP. Methods Mol Biol. 2007. 364:215-30.

Technical Notes

SHARP/autoSHARP is installed on our server at Harvard Medical School. Please email help@sbgrid.org to gain access.

License Type

This software is distributed under a Non-Profit license.

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